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Research Affairs

S.D. School of Mines & Technology
501 E. St. Joseph Street
Suite 102, O'Harra Building
Rapid City, SD  57701

(605) 394-2493

Research@Mines - by Subject
Medical Research

Engineering End to Back Pain

Marit Johnson, a PhD candidate at SD Mines, is focusing her research on intervertebral discs in the lower back.

There is a good chance you are sitting down right now. It’s possible you’ve been sitting all day, or maybe you’ve even been sitting every day for the last few decades.

“There is a trend in the 21st century that 80 percent of our jobs require sitting, and it’s even more so when you include leisure time,” says Marit Johnson (CE 96), a PhD candidate in biomedical engineering at SD Mines.

You may guess that spending all this time in a chair is not so good for your health. In fact, research is now showing prolonged sitting may contribute to lower back pain. “Eighty percent of us will experience back pain in our lifetime,” says Johnson. "If your job requires long hours in a chair, back pain can be a real issue."

Johnson’s research is focused on the intervertebral discs of the lower back. These discs are in between the vertebrae, or bones, of the spine, and their softer tissue provides cushion and flexibility. They are key components of a healthy and functional spine.

Research shows that intervertebral discs need to exchange fluid to maintain a healthy environment, similar to how our bodies need breathing to exchange carbon dioxide with oxygen for our survival. “Typically, when we wake up in the morning we’re taller,” says Johnson. At night when we sleep the discs pull in fluid and they expand. As the day goes on,...

Last Edited 5/25/2018 11:36:38 AM [Comments (0)]

Microscopy Trifecta Examines How Cells Engulf Nutrients, Viruses

As part of her doctoral research at the South Dakota School of Mines & Technology nanoscience and nanoengineering program, Amy Hor examines chemically fixed cells using correlated fluorescence and atomic force microscopy. She worked under the direction of professor Steve Smith. The collaborative research, which also involved microscopy teams from South Dakota State University and the National Institutes of Health, showed that membrane bending occurs at all stages of clathrin assembly.

Scientists have a better understanding of a mechanism that allows cells to internalize beneficial nutrients and not-so-beneficial viruses, thanks to collaboration among researchers from two South Dakota universities and the National Institutes of Health.           

South Dakota State University associate professor Adam Hoppe, South Dakota School of Mines & Technology professor Steve Smith and NIH scientists Justin Taraska and Kem Sochacki combined three unique types of microscopy to track how a protein called clathrin triggers cell membrane bending. They found that clathrin, which creates a honeycomb shaped scaffold on the cell membrane, has an unexpected amount of plasticity when pinching off small portions of the cell membrane. Their work was published in the Jan. 29, 2018, issue of Nature Communications.

Hoppe and Smith work collaboratively through the South Dakota BioSystems Networks and Translational Research (BioSNTR) center, which is funded through the South Dakota Research Innovation Center program and the National Science Foundation’s Established Program to Stimulate Competitive Research program. A greater understanding of how cells internalize material will help BioSNTR researchers working with Sioux Falls-based SAB Biotheraputics to develop new alternative treatments for influenza.

The contributions of NIH scientists Justin Taraska and Kem Sochacki were made possible through a federally fund...

Last Edited 4/26/2018 01:37:40 PM [Comments (0)]