A South Dakota Mines research team has developed technology – and established a subsequent startup company – that could be a key to finding a cure for osteoarthritis.

Scott Wood, Ph.D., an assistant professor in the NanoScience and NanoEngineering Program, and Ph.D. student Ram Saraswat lead the research and development of the nanoscience technology now utilized by their startup, CellField Technologies. “We’re excited about the potential future of the technology and the company,” Wood says. “We hope it will be a gamechanger in osteoarthritis research.”

Osteoarthritis, sometimes called degenerative joint disease, is the most common form of arthritis. Most often it occurs in the hands, hips and knees. Osteoarthritis develops when the cartilage within a joint begins to break down, causing pain, stiffness and swelling. More than 32.5 million adults in the United States suffer from osteoarthritis, and current treatments offer little more than temporary pain control, Wood says. 

Wood says that for hundreds of years, doctors have considered...

Epidemiologists at South Dakota Mines say misinformation about the COVID-19 vaccine currently circulating on the internet may frighten some people away from becoming inoculated. 

South Dakota Mines is installing a new Scanning Electron Microscope (SEM) in the university’s Engineering and Mining Experiment Station (EMES) thanks to a $1.3 million grant from the National Science Foundation. The new microscope is just one of many state-of-the-art scientific instruments inside the recently expanded EMES which serves high-tech industry alongside university researchers across the state.

The powerful SEM microscope is a centerpiece of the EMES. It allows researchers to perform high resolution imaging, chemical analysis and sample manipulation for various materials at scales ranging down to 100,000 times smaller than the width of a human hair. The new microscope is a critical resource for a wide variety of research across multiple disciplines.

“The SEM is the most heavily used research instrument on campus,” says Grant Crawford, Ph.D., the director of the Arbegast Materials Processing and Joining Laboratory at Mines and an associate professor in the Department of Materials and Metallurgical Engineering.

The new SEM is equipped with a focused ion beam that dramatically expands its capability over the old system. The ion beam allows researchers to extract samples for separate analysis and cr...

The Engineering and Mining Experiment Station (EMES) at South Dakota Mines has begun overseeing the operation and maintenance of instrumentation within the Shimadzu Environmental Research Laboratory (SERL).

The EMES was founded on the Mines campus in 1903 with a mission to serve mining industry research. Today the mission has expanded to include a much broader range of academic and industry needs with a wide array of scientific equipment that is utilized by industry professionals and university researchers across the region. The EMES has seen equipment investments by the South Dakota Board of Regents and the National Science Foundation totaling more than $2.8 million since 2011. The EMES website lists the range of scientific equipment available for academic research and industry use including the Shimadzu instrumentation.

The SERL was established in 2015 in partnership with Shimadzu Scientific Instruments by Lisa Kunza. Ph.D., associate professor in the Department of Chemistry Biology and Health Sciences at Mines. The SERL is a multidisciplinary research facility that contains a suite of state-of-the-art instrumentation with a focus on environmental applications. SERL instruments enable the chemical characterization of a wide range of sample types including natural waters, biological materials, roc...

As a mechanical engineering graduate from South Dakota Mines, Joree Sandin never expected to do medical research, but the 2018 graduate has spent the past two years focused on antibiotic resistant infections. 

“Three or four years ago, as a mechanical engineering major at Mines, I would never have imagined that I would have gained this experience … my car took a random exit toward this bio world and I’m so glad it did,” she says. 

Sandin recently completed her master’s in mechanical engineering from the University of Kentucky College of Engineering. She returned to Mines in October to co-present the research seminar, “A Mechanical Engineer’s Approach to Bacterial Infections,” alongside Dr. Martha E. Grady, assistant professor in mechanical engineering at UK and lead researcher on the work. 

The UK research Sandin has been a part of focuses on biofilm formations, specifically in dental care.  

Biofilms are a collection of microorganisms that grow on surfaces. The microorganisms that make up biofilms can include bacteria, protists and fungi. “Biofilms are really everywhere,” Sandin say...

In the past three years, the National Science Foundation (NSF) has awarded  $32 million in funding for research led by faculty at South Dakota School of Mines & Technology that expands human understanding of the microbial world. Much of the research focuses on the environment microbes occupy when they attach to surfaces and create what is commonly known as a biofilm.

The broad range of studies on microbes and biofilms, funded by these grants, has a wide potential for applications across many sectors of industry and society including energy generation, new medicines, wastewater purification, agriculture, corrosion resistance, new materials and reduction of greenhouse gas emissions.

The research effort of the newly announced $20 million NSF grant titled “Building on the 2020 Vision: Expanding Research, Education and Innovation in South Dakota” will be led by researchers at SD Mines, SDSU and USD. The funding was awarded through the South Dakota Established Program to Stimulate Competitive Research (SD EPSCoR) and the South Dakota Board of Regents. The state of South Dakota is providing $4 million in matching funds for the grant. The Governor’s office of Economic Development and Board of Regents are providing $3 million and there is ...

This year, the Nobel Prize in Physics was awarded to three individuals for “groundbreaking inventions in the field of laser physics”: Arthur Ashkin with Bell Laboratories in the United States; Gerard Mourou of the École Polytechnique, Palaiseau, France, and the University of Michigan, Ann Arbor; and Donna Strickland from the University of Waterloo in Canada.

Steve Smith, who earned his Ph.D. doing research in a National Science Foundation Science and Technology Center directed by Mourou at the University of Michigan, was pleased to hear Mourow was receiving a share of the Nobel Prize.

“It’s nice he received a part of this prize. But it also gives acknowledgement to a lot of people in different areas of laser physics. That’s usually how it works—one person gets the prize but there are hundreds of people doing similar work that is very impactful, and this elevates their research as well,” said Smith, who is a professor and director of Nanoscience and Nanoengineering at the South Dakota School of Mines & Technology (SD Mines).

At Deep Talks: Nobel Day, Smith will discuss the topics relating to this year's Nobel Prize in Physics, including Mourou’s work in the field of laser physics and how it has impacted a variety of scientific and technologica...

There is a good chance you are sitting down right now. It’s possible you’ve been sitting all day, or maybe you’ve even been sitting every day for the last few decades.

“There is a trend in the 21st century that 80 percent of our jobs require sitting, and it’s even more so when you include leisure time,” says Marit Johnson (CE 96), a PhD candidate in biomedical engineering at SD Mines.

You may guess that spending all this time in a chair is not so good for your health. In fact, research is now showing prolonged sitting may contribute to lower back pain. “Eighty percent of us will experience back pain in our lifetime,” says Johnson. "If your job requires long hours in a chair, back pain can be a real issue."

Johnson’s research is focused on the intervertebral discs of the lower back. These discs are in between the vertebrae, or bones, of the spine, and their softer tissue provides cushion and flexibility. They are key components of a healthy and functional spine.

Research shows that intervertebral discs need to exchange fluid to maintain a healthy environment, similar to how our bodies need breathing to exchange carbon dioxide with oxygen for our survival. “Typically, when we wake up in the morning we’re taller,” says Johnson. At night when we sleep the discs pull in fluid and they expand. As the day goes on,...

Scientists have a better understanding of a mechanism that allows cells to internalize beneficial nutrients and not-so-beneficial viruses, thanks to collaboration among researchers from two South Dakota universities and the National Institutes of Health.           

South Dakota State University associate professor Adam Hoppe, South Dakota School of Mines & Technology professor Steve Smith and NIH scientists Justin Taraska and Kem Sochacki combined three unique types of microscopy to track how a protein called clathrin triggers cell membrane bending. They found that clathrin, which creates a honeycomb shaped scaffold on the cell membrane, has an unexpected amount of plasticity when pinching off small portions of the cell membrane. Their work was published in the Jan. 29, 2018, issue of Nature Communications.

Hoppe and Smith work collaboratively through the South Dakota BioSystems Networks and Translational Research (BioSNTR) center, which is funded through the South Dakota Research Innovation Center program and the National Science Foundation’s Established Program to Stimulate Competitive Research program. A greater understanding of how cells internalize material will help BioSNTR researchers working with Sioux Falls-based SAB Biotheraputics to develop new alternative treatments for influenza.

The contributions of NIH scientists Justin Taraska and Kem Sochacki were made possible through a federally fund...